2022-present:

GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1

M Muller, J Bélanger, I Hadj-Aissa, C Zhang, CF Sephton, PA Dutchak

International Journal of Molecular Sciences 25 (4), 2068

 

Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition

MC Pelaez, A Desmeules, PA Gelon, B Glasson, L Marcadet, A Rodgers, ...CF Sephton

Acta Neuropathologica Communications 11 (1), 182

 

Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS

MF Comaduran, S Minotti, S Jacob-Tomas, J Rizwan, N Larochelle, ...R Robitaille, CF Sephton, M Vera, JN Nalbantoglu, HD Durham

bioRxiv, 2023.12. 13.571549

 

Antisense oligonucleotides targeting miR‐29b binding site increase translation of progranulin protein: potential therapeutic strategy for progranulin‐deficient frontotemporal …

G Aggarwal, S Banerjee, SA Jones, M Pavlack, Y Benchaar, J Bélanger, ...CF Sephton, A Nguyen

Alzheimer's & Dementia 18, e067828

 

Widespread alterations in microRNA biogenesis in human Huntington’s disease putamen

S Petry, R Keraudren, B Nateghi, A Loiselle, K Pircs, J Jakobsson, CF Sephton, M Langlois, I St-Amour, SS Hébert

Acta Neuropathologica Communications 10 (1), 1-11

 

Synaptic dysfunction in ALS and FTD: Anatomical and molecular changes provide insights into mechanisms of disease

PA Gelon, PA Dutchak, CF Sephton

Frontiers in Molecular Neuroscience 15, 1000183

 

P241. Dissecting the Contribution of the Cortico-Striatal and Cortico-Tegmental Pathways to Stress Responses

T Bittar, S Mansourie, MC Pelasez, JCH Silva, C Sephton, C Proulx, TH Chen, B Labonté

Biological Psychiatry 91 (9), S184-S185

 

NPRL2 inhibition of mTORC1 controls sodium channel expression and brain amino acid homeostasis

JB Hui, JCH Silva, MC Pelaez, M Sévigny, JP Venkatasubramani, ...CF Sephton, PA Dutchak

Eneuro 9 (2)

 

A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics

G Nicolas, M Sévigny, F Lecoquierre, F Marguet, A Deschênes, ...A Rovelet-Lecrux, CF Sephton

Acta neuropathologica communications 10 (1), 20

 

2021-2018:

hnRNP A1B, a Splice Variant of HNRNPA1, Is Spatially and Temporally Regulated

M Gagné, JE Deshaies, H Sidibé, Y Benchaar, D Arbour, A Dubinski, ...CF Sephton, C Vande Velde

Frontiers in Neuroscience 15, 724307

 

Chronic stress induces sex-specific functional and morphological alterations in corticoaccumbal and corticotegmental pathways

TP Bittar, MC Pelaez, JCH Silva, F Quessy, AA Lavigne, D Morency, ...CF Sephton, CD Proulx, B Labonté

Biological Psychiatry 90 (3), 194-205

 

FUS contributes to mTOR-dependent inhibition of translation

M Sévigny, IB Julien, JP Venkatasubramani, JB Hui, PA Dutchak, CF Sephton

Journal of Biological Chemistry 295 (52), 18459-18473

 

Sex-Specific Molecular and Cellular Adaptations to Chronic Stress in NAc-and VTA-Projecting Pyramidal Neurons of the mPFC

T Bittar, JC Hernandez, MC Pelaez, D Morency, K Abdallah, A Barbeau, CF Sephton, CD Proulx, B Labonté

NEUROPSYCHOPHARMACOLOGY 44 (SUPPL 1), 322-323

 

Metabolic networks influencing skeletal muscle fiber composition

I Bourdeau Julien, CF Sephton, PA Dutchak

Frontiers in cell and developmental biology 6, 125

 

The function of RNA-binding proteins at the synapse: implications for neurodegeneration

CF Sephton, G Yu

Cellular and Molecular Life Sciences 72, 3621-3635

 

2017-2010:

Activity-dependent FUS dysregulation disrupts synaptic homeostasis

CF Sephton, AA Tang, A Kulkarni, J West, M Brooks, JJ Stubblefield, Y Liu, ...G Yu

Proceedings of the National Academy of Sciences 111 (44), E4769-E4778

 

Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD

ME Ward, A Taubes, R Chen, BL Miller, CF Sephton, JM Gelfand, ...Li Gan

Journal of Experimental Medicine 211 (10), 1937-1945

 

Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration

B Cenik, CF Sephton, BK Cenik, J Herz, G Yu

Journal of Biological Chemistry 287 (39), 32298-32306

 

TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration

CF Sephton, B Cenik, BK Cenik, J Herz, G Yu

Biological chemistry 393 (7), 589-594

 

TDP-43 aggregation in neurodegeneration: are stress granules the key?

CM Dewey, B Cenik, CF Sephton, BA Johnson, J Herz, G Yu

Brain research 1462, 16-25

 

γ-Secretase-regulated proteolysis of the Notch receptor by mitochondrial intermediate peptidase

SF Lee, B Srinivasan, CF Sephton, DR Dries, B Wang, C Yu, Y Wang, ...G Yu

Journal of Biological Chemistry 286 (31), 27447-27453

 

Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia

B Cenik, CF Sephton, CM Dewey, X Xian, S Wei, K Yu, W Niu, G Coppola, ...G Yu, J Herz

Journal of Biological Chemistry 286 (18), 16101-16108

 

TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor

CM Dewey, B Cenik, CF Sephton, DR Dries, P Mayer III, SK Good, ...G Yu

Molecular and cellular biology 31 (5), 1098-1108

 

Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes*♦

CF Sephton, C Cenik, A Kucukural, EB Dammer, B Cenik, YH Han, ...M Moore, G Yu

Journal of biological chemistry 286 (2), 1204-1215

 

SAHA (VORINOSTAT) upregulates progranulin transcription: a rational therapeutic approach to frontotemporal dementia

B Cenik, CF Sephton, CM Dewey, X Xian, S Wei, K Yu, W Niu, G Coppola, ...

J Biol Chem 286 (18), 16101-16108

 

TDP-43 is a developmentally regulated protein essential for early embryonic development

CF Sephton, SK Good, S Atkin, CM Dewey, P Mayer, J Herz, G Yu

Journal of Biological Chemistry 285 (9), 6826-6834